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    Helosciadium crassipes Koch (Apiaceae) extracts as natural sunscreen and preservative additives
    (Horticulture and Forestry Society from Transylvania, 2023) Makhloufi, El-Hani; Lefahal, Mostefa; Ayad, Radia; Çakmak, Yavuz Selim; Nieto, Gema; Akkal, Salah
    Recently, ingredients derived from natural sources have gained increasing interest in the cosmetic field due to their low toxicity. Therefore, this study was designed to explore the cosmetic potential of Helosciadium crassipes Koch (Apiaceae) species growing in Algeria as a promising natural preservative and broad-spectrum UV protection additive. In our study, the in-vitro antioxidant effect was assessed via DPPH radical scavenging and total antioxidant capacity by phosphomolybdenum method (TAC), while the protection against UVB radiation was evaluated according to the sun protection factor (SPF) by using UV spectroscopic technic at wavelengths ranging from 290 to 320 nm and Mansur’s equation, for the photoprotective effect against long-wavelength UVA, UVA/UVB and critical wavelength (?c) parameters were evaluated. The outcomes showed that among the tested extracts, the methanolic extract (MeOH) contains high levels of phenolics and flavonoids, and possesses a significant antioxidant effect, particularly in DPPH radical scavenging assay. Similarly, this last one exhibited high photoprotective activity in UVB and UVA ranges. The gathered results reveal the possibility of using this extract as a good natural additive to be incorporated into cosmetic formulations as a broad-spectrum UV protection candidate and as a preservative agent
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    In vitro antioxidant and antimicrobial activities of aerial parts of Algerian Jurinea humilis DC (Asteraceae)
    (Pharmacotherapy Group, 2017) Ayad, Radia; Çakmak, Yavuz S.; Özüsağlam, Meltem A.; Medjroubi, Kamel; Akkal, Salah
    Purpose: To assess the polyphenolic composition of various solvent extracts of Jurinea humilis DC. as well as their in vitro biological effects. Methods: The crude extracts of the aerial parts of Jurinea humilis were obtained by maceration method with dichloromethane (DCM), methanol (MeOH) and ethyl acetate (EtoAC), separately. Folin-Ciocalteu and aluminum chloride procedures were used to quantify the total phenolic and flavonoid contents, respectively, while antioxidant properties were determined by two methods: phosphomolybdenum and DPPH assays. Antimicrobial activity was also evaluated by disc diffusion method. Results: The ethyl acetate extract exhibited the highest amount of total phenolic content (TPC, 169.14 +/- 7.22 mg gallic acid equivalent/g sample) and total flavoniod contents (TFC, 104.91 +/- 0.22 mg rutin equivalent/g sample). The extract (EtoAC) also showed the strongest antioxidant activity of the three extracts, especially DPPH assay (IC50 = 0.16 +/- 0.00 mg/mL), as well as demonstrated the highest activity against the pathogenic strains tested. Conclusion: The results suggest that J. humilis DC. is rich in phenolic and flavonoid contents which may be responsible for good antioxidant and antimicrobial properties. Thus, J. humilis may be a promising source of new antioxidant agents and pharmaceuticals.