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  • Küçük Resim
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    Comparison of the effects of Autologous Cytokine-rich Serum (ACRS) and Platelet-Rich Plasma (PRP) on skin wound healing
    (Sciendo, 2025) Erol, Hanifi; Karakaş, Erol; Ermiş, Mustafa; Akçakavak, Gökhan; Aslan, Nevzat Emre; Karataş, Özhan
    Wound healing is one of the most complex biological events, involving physiological processes such as tissue restoration and intricate cellular and molecular activities. The aim of this study was to investigate the effects of Autologous Cytokine Rich Serum (ACRS) and Platelet-rich plasma (PRP) on wound healing and to compare their impact on tissue repair using histopathological and immunohistochemical methods. A total of 42 healthy Wistar-Albino rats were used as material. The histopathological and immunohistochemical evaluations showed that ACRS is more effective than PRP on wound healing. The superior efficacy of ACRS is attributed to its stimulation of anti-inflammatory cytokines and provision of essential nutrients such as amino acids, vitamins, and lipids. Further detailed studies are recommended to explore these findings.
  • Küçük Resim
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    Investigation of the Effect of Autologous Cytokine Rich Serum (ACRS) and Platelet Rich Plasma (PRP) Treatment on Experimental Uterine Horn Peritoneal Adhesion Model in Rats
    (Springer International Publishing, 2025) Erol, Hanifi; Karakaş, Erol; Akçakavak, Gökhan; Aslan, Nevzat Emre; Karataş, Özhan
    Adhesion formation is a complex biological process defined as adhesion of intra-abdominal organs to one another or to the abdominal wall with fibrous bands. In recent years, various methods and drugs have been used for preventing the abdominal adhesion. Autologous cytokine rich serum (ACRS) is a blood-derived product obtained by incubating and centrifuging whole blood. It contains various cytokines and factors. Platelet rich plasma (PRP) is a blood product and rich in growth factors. Objective: The aim of this study is to compare and investigate the effects of PRP and ACRS on uterine horn peritoneal adhesion. Methods: The animal material of the study was consisted 42 healthy, 4 months old, non-pregnant female Wistar-Albino rats with 150–200 g, body weight. While 6 of these 42 animals included in the study were used as donors to PRP and ACRS, 36 animals were divided into six groups with 6 rats in each group. Result: Adhesion, inflammatory cell infiltration, TNF-α, IL-6, Col-I, α-SMA scores were compared between groups and ACRS group’s scores were significantly lower than other groups. Conclusion: As result of this study, ACRS treatment has shown to provide more effective manipulation of the inflammatory response. Especially, ACRS treatment has more effective anti-inflammatory effect on peritoneal adhesion was seen with the histopathologic findings of this study. Our current findings suggest that ACRS has an anti-adhesion role by reducing the inflammatory response in adhesion tissues.