Examination of the obesogenic effects of bisphenol-A
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The prevalence of obesity among people has increased dramatically in recent years in all theworld. It is not enough to explain this increasing trend only with people's lifestyle, eating habitsand cultural differences. Some chemicals, which are taken into the human body, especiallythrough the food chain and are considered to be endocrine disruptors, affect the frequency ofobesity. Endocrine disrupting chemicals (EDCs) are compounds that cause hormone disruptionand elimination of the functions of these hormones. Bisphenol-A (BPA) is one of the mostintensive chemicals in human life and is generally called 2,2-bis (4-hydroxyphenyl) propane.70% of the BPA in the world is used in polycarbonate plastics and 30% in epoxy resins. Due tothe widespread usage of it, BPA reaches solid and liquid wastes in terrestrial and aquaticecosystems in large quantities. Considering the high production capacity of BPA and its differentapplication areas, it is claimed that significant amount of BPA enters the environment. Studiesshow that the rate of being exposed to BPA has an increasing tendency. In the literature, the rateof availability in drinking water and the data on the reproductive system were only included inthe researches related to BPA. Therefore, this study aimed to observe the obesogenic role ofBPA in the development of obesity, which is the current health problem of the world. BPA is anendocrine disrupting chemical known to have in vitro effects on glucose metabolism and adiposetissue. In a limited number of clinical and epidemiological studies, BPA has been shown to beassociated with diabetes and obesity. For this purpose, the current literature related to this issuehas been reviewed and the effects of BPA on obesity have been compiled both in the world andin our country.