• The quantification of mitochondria in different synapse types in the prefrontal cortex using stereological techniques 

  İkinci Keleş, Ayşe (Nova Science Publishers, Inc., 2024)

  The prefrontal cortex (PFC) lies in the anterior part of the brain, constitutes a large part of the central nervous system, and is of great importance to socio-emotional and executive functions crucial to numerous cognitive ...

• Protective effects of syringic acid against oxidative damage, apoptosis, autophagy, inflammation, testicular histopathologic disorders, and impaired sperm quality in the testicular tissue of rats induced by mercuric chloride 

  Akarsu, Serkan Ali; Gür, Cihan; Küçükler, Sefa; Akaras, Nurhan; İleritürk, Mustafa; Kandemir, Fatih Mehmet (John Wiley and Sons Inc, 2024)

  Mercury (Hg) is one of the most toxic heavy metals that damage testicular tissue. Mercury chloride (HgCl2) is one of the most toxic forms of mercury that can easily cross biological membranes. Syringic acid (SA) is a natural ...

• Functional and structural neurodegenerative activities of Ankaferd BloodStopper in a mouse sciatic nerve model 

  Üstün, Ramazan; Kaval Oğuz, Elif; Şeker, Ayşe; Taşpınar, Filiz (Spandidos Publications, 2024)

  Traumatic and postoperative hemorrhages are life-threatening complications. Ankaferd BloodStopper (ABS) is a potent topical hemostatic agent to stop bleeding. However, ABS is associated with nerve toxicity. The present ...

• Ameliorative effects of sinapic acid against vancomycin-induced testicular oxidative damage, apoptosis, inflammation, testicular histopathologic disorders and decreased epididymal sperm quality 

  Akarsu, Serkan Ali; İleritürk, Mustafa; Küçükler, Sefa; Akaras, Nurhan; Gür, Cihan; Kandemir, Fatih Mehmet (Elsevier, 2024)

  In this study, it was aimed to determine the effect of sinapic acid (SNP), a polyphenol with antioxidant, anti-inflammatory and antibacterial properties, on testicular damage caused by vancomycin (VCM), a widely used ...

• Comparison of the effects of Ho: YAG laser virtual Basket™ pulse modulation and Thulium fiber laser on kidney tissue – an ex vivo experimental study 

  Emin Şirin, Mehmet; Karaaslan, Mustafa; Ordu, Melike; Yılmaz, Mehmet (Springer Science and Business Media Deutschland GmbH, 2024)

  Through an ex vivo experimental study, we aimed to compare the effects of the Ho: YAG laser Virtual Basket (VB™) modulation and a Thulium fiber laser (TFL) on kidney tissue in different environments and using laser ...

• Computed tomography based evaluation of the association between sphenoid sinus pneumatization patterns and variations of adjacent bony structures in relation to age and gender 

  Açar, Gülay; Gökşan, Ahmet Safa; Aydoğdu, Demet (Springer Science and Business Media Deutschland GmbH, 2024)

  Many studies revealed that the sphenoid sinus pneumatization (SSP) affects the protrusion/dehiscence of adjacent structures including optic canal (OC), foramen rotundum (FR), vidian canal (VC), and carotid canal (CC). ...

• Protective effects of hesperidin in gastric damage caused by experimental ischemia-reperfusion injury model in rats 

  Özyigit, Filiz; Değer, Ayşe Nur; Koçak, Fatma Emel; Ekici, Mehmet Fatih; Simşek, Hasan; Arık, Özlem (Sociedade Brasileira para o Desenvolvimento de Pesquisa em Cirurgia, 2024)

  This study evaluated the protective effect of hesperidin on injury induced by gastric ischemia-reperfusion. Methods: Fifty male Sprague Dawley rats (250–300 g) were divided into five groups: control (C), sham (S), ischemia ...

• Naringin protects against colistin-induced sciatic nerve damage by reducing oxidative stress, apoptosis and inflammation damage 

  Yılmaz, Selçuk; Küçükler, Sefa; Şi̇mşek, Hasan; Aygörmez, Serpil; Kandemir, Fatih Mehmet (Ondokuz Mayis Universitesi, 2024)

  Colistin is used in treatment against gram-negative bacteria. It causes toxic effects due to oxidative stress in a dose-dependent manner. Naringin is a flavonoid with strong antioxidant properties found naturally in many ...

• Therapeutic Potential of Silymarin in Mitigating Paclitaxel-Induced Hepatotoxicity and Nephrotoxicity: Insights into Oxidative Stress, Inflammation, and Apoptosis in Rats 

  Yakut, Seda; Atcalı, Tuğçe; Çağlayan, Cüneyt; Ulucan, Aykut; Kandemir, Fatih Mehmet; Kara, Adem; Anuk, Turgut (Galenos Publishing House, 2024)

  Paclitaxel (PAX) is a widely used chemotherapy drug for various cancer types but often induces significant toxicity in multiple organ systems. Silymarin (SIL), a natural flavonoid, has shown therapeutic potential due to ...

• FDA approves the first HPV self-collection solutions 

  Bilir, Esra; Saçıntı, Koray Görkem; Kacperczyk-Bartnik, Joanna; Gültekin, Murat (BMJ Publishing Group, 2024)

  ...

• Protective effects of naringin on colistin-induced damage in rat testicular tissue: Modulating the levels of Nrf-2/HO-1, AKT-2/FOXO1A, Bax/Bcl2/Caspase-3, and Beclin-1/LC3A/LC3B signaling pathways 

  Kankılıç, Nazım Abdülkadir; Şimşek, Hasan; Akaras, Nurhan; Gür, Cihan; İleritürk, Mustafa; Küçükler, Sefa; Akarsu, Serkan A.; Kandemir, Fatih M. (John Wiley and Sons Inc, 2024)

  Antimicrobial agent resistance has become a growing health issue across the world. Colistin (COL) is one of the drugs used in the treatment of multidrug-resistant bacteria resulting in toxic effects. Naringin (NRG), a ...

• The Relation between Plasma Nesfatin-1 Levels and Aggressive Behavior in Pit Bull Dogs 

  Güvenç Bayram, Gökçen; Semen, Zeynep; Polat Dinçer, Pelin Fatoş; Sertkaya, Zeynep Tuğçe; Üstündağ, Yasemin; Ateş, Can; Aktaş, Buğra; Yalçın, Murat (Multidisciplinary Digital Publishing Institute (MDPI), 2024)

  Aggression is a prevalent and concerning behavioral issue in dogs. Pit Bull dogs, known for their high levels of aggression, are recognized as a focus of concern in society. In our study, we aimed to investigate the ...

• Investigation of some changes and clonal relationship in enterococci isolates due to relocation of a hospital 

  Korkoca, Hanifi; Hazırolan, Gülşen; Çiçek, Cemal; Savaş, Sümeyra; Akgül, Ömer; Tanrıverdi, Elif Seren (Pakistan Medical Association, 2024)

  To investigate the isolation rates, antimicrobial resistance rates, minimum inhibitory concentration values of antimicrobial agents, and clonal relationships of Enterococcus faecalis and Enterococcus faeciumdue to the ...

• Exploring the combined anti-cancer effects of sodium butyrate and celastrol in glioblastoma cell lines: a novel therapeutic approach 

  Kartal, Bahar; Denizler Ebiri, Farika Nur; Güven, Mustafa; Taşpınar, Filiz; Canpınar, Hande; Çetin, Sedat; Karaduman, Tuğçe; Küçüktürk, Serkan; Castresana, Javier; Taşpınar, Mehmet (Springer, 2024)

  Glioblastoma, a highly aggressive and lethal brain cancer, lacks effective treatment options and has a poor prognosis. In our study, we explored the potential anti-cancer effects of sodium butyrate (SB) and celastrol (CEL) ...

• A TNF-α inhibitor abolishes sepsis-induced cognitive impairment in mice by modulating acetylcholine and nitric oxide homeostasis, BDNF release, and neuroinflammation 

  Öz, Mehmet; Erdal, Hüseyin (Elsevier B.V., 2024)

  Neurodegenerative disorders have a pathophysiology that heavily involves neuroinflammation. In this study, we used lipopolysaccharide (LPS) to create a model of cognitive impairment by inducing systemic and neuroinflammation ...

• Sinapic acid protects against lead acetate-induced lung toxicity by reducing oxidative stress, apoptosis, inflammation, and endoplasmic reticulum stress damage 

  Akaras, Nurhan; Küçükler, Sefa; Gür, Cihan; İleritürk, Mustafa; Kandemir, Fatih Mehmet (John Wiley and Sons Inc, 2024)

  Lead acetate (PbAc) is a compound that produces toxicity in many tissues after exposure. Sinapic acid (SNP) possesses many biological and pharmacological properties. This study aimed to investigate the efficacy of SNP on ...

• Naringin protects against paclitaxel-induced toxicity in rat testicular tissues by regulating genes in pro-inflammatory cytokines, oxidative stress, apoptosis, and JNK/MAPK signaling pathways 

  Kankılıç, Nazım Abdülkadir; Küçükler, Sefa; Gür, Cihan; Akarsu, Serkan Ali; Akaras, Nurhan; Şimşek, Hasan; İleritürk, Mustafa; Kandemir, Fatih Mehmet (John Wiley and Sons Inc, 2024)

  Paclitaxel (PTX), which is actively used in the treatment of many types of cancer, has a toxic effect by causing increased oxidative stress in testicular tissues. Naringin (NRG) is a natural flavonoid found in plants, and ...

• The ameliorative effects of chrysin on bortezomib-induced nephrotoxicity in rats: Reduces oxidative stress, endoplasmic reticulum stress, inflammation damage, apoptotic and autophagic death 

  Kankılıç, Nazım Abdülkadir; Şimşek, Hasan; Akaras, Nurhan; Gür, Cihan; Küçükler, Sefa; Gencer, Selman; Kandemir, Fatih Mehmet (Elsevier Ltd, 2024)

  Bortezomib is a proteasome inhibitor antineoplastic agent that was the first to be approved for cancer treatment. One of bortezomib's most prominent dose-limiting effects is nephrotoxicity; the underlying mechanism is ...

• The Protective Role of Syringic Acid on Ovarian Injury Created by Ischemia Reperfusion 

  Topdağı Yılmaz, Emsal Pınar; Tanyeli, Ayhan; Eraslan, Ersen; Güler, Mustafa Can; Ekinci Akdemir, Fazile Nur; Güzel Erdoğan, Derya; Taşpınar, Filiz (Van Yüzüncü Yıl Üniversitesi Tıp Fakültesi, 2024)

  Syringic acid (SA), a natural phenolic substance, possesses anti-inflammatory and antioxidant properties. We investigated the likely preventive effects of SA on organ damage to the reproductive system caused by bilateral ...

• Abamektin kaynaklı mide toksisitesinde hesperidinin oksidatif stres, inflamasyon ve apoptoz üzerindeki koruyucu etkisi 

  Tuncer, Sibel Çiğdem; Gür, Cihan; Şimşek, Hasan; Kandemir, Fatih Mehmet (Ayşe SURUÇ, 2024)

  Abamektin günümüzde tarım endüstrisinde çok fazla kullanılan bir pestisit türü olup uzun süreli maruziyet sonucunda toksik etkilere sahiptir. Uzun süreli abamektin maruziyeti sonucunda özellikle oksidatif stres ilişkili ...

View more