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dc.contributor.authorKankılıç, Nazım Abdülkadir
dc.contributor.authorŞimşek, Hasan
dc.contributor.authorAkaras, Nurhan
dc.contributor.authorGür, Cihan
dc.contributor.authorİleritürk, Mustafa
dc.contributor.authorKüçükler, Sefa
dc.contributor.authorAkarsu, Serkan A.
dc.contributor.authorKandemir, Fatih M.
dc.date.accessioned2024-07-12T06:32:10Z
dc.date.available2024-07-12T06:32:10Z
dc.date.issued2024en_US
dc.identifier.issn10956670
dc.identifier.urihttps:/dx.doi.org/10.1002/jbt.23643
dc.identifier.urihttps://hdl.handle.net/20.500.12451/12116
dc.description.abstractAntimicrobial agent resistance has become a growing health issue across the world. Colistin (COL) is one of the drugs used in the treatment of multidrug-resistant bacteria resulting in toxic effects. Naringin (NRG), a natural flavonoid, has come to the fore as its antioxidant, anti-inflammatory, and antiapoptotic activities. The aim of the present study was to determine whether NRG has protective effects on COL-induced toxicity in testicular tissue. Thirty-five male Spraque rats were randomly divided into five groups (n = 7 per group): Control, COL, NRG, COL + NRG 50, COL + NRG 100. COL (15 mg/kg b.w., i.p., once per/day), and NRG (50 or 100 mg/kg, oral, b.w./once per/day) were administered for 7 days. The parameters of oxidative stress, inflammation, apoptosis, and autophagic damage were evaluated by using biochemical, molecular, western blot, and histological methods in testicular issues. NRG treatment reversed the increased malondialdehyde level and reduced antioxidants (superoxide dismutase, catalase, glutathione peroxidase, and glutathione) levels due to COL administration (p < 0.001), and oxidative stress damage was mitigated. Nuclear factor erythroid 2-related factor-2 pathway, one of the antioxidant defence systems, was stimulated by NRG (p < 0.001). NRG treatment reduced the levels of markers for the pathways of apoptotic (p < 0.001) and autophagic (p < 0.001) damages induced by COL. Sperm viability and the live/dead ratio were reduced by COL but enhanced by NRG treatment. Testicular tissue integrity was damaged by COL but showed a tendency to improve by NRG. In conclusion, COL exhibited toxic effect on testicular tissue by elevating the levels of oxidative stress, apoptosis, autophagy, inflammation, and tissue damage. NRG demonstrated a protective effect by alleviating toxic damage.en_US
dc.language.isoengen_US
dc.publisherJohn Wiley and Sons Incen_US
dc.relation.isversionof10.1002/jbt.23643en_US
dc.rightsinfo:eu-repo/semantics/embargoedAccessen_US
dc.subjectApoptosisen_US
dc.subjectAutophagyen_US
dc.subjectColistinen_US
dc.subjectNaringinen_US
dc.subjectOxidative Stressen_US
dc.subjectTesticular Toxicityen_US
dc.titleProtective effects of naringin on colistin-induced damage in rat testicular tissue: Modulating the levels of Nrf-2/HO-1, AKT-2/FOXO1A, Bax/Bcl2/Caspase-3, and Beclin-1/LC3A/LC3B signaling pathwaysen_US
dc.typearticleen_US
dc.relation.journalJournal of Biochemical and Molecular Toxicologyen_US
dc.contributor.departmentTıp Fakültesien_US
dc.contributor.authorID0000-0002-3747-3798en_US
dc.contributor.authorID0000-0001-6775-7858en_US
dc.contributor.authorID0000-0002-4581-4492en_US
dc.contributor.authorID0000-0003-4450-6540en_US
dc.identifier.volume38en_US
dc.identifier.issue2en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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