Erdoğan, KenanÖrün, Gül NihalKorkmaz, NuhErkmen, BeldaPolat, HüseyinDoğru, ArzuÖrün, İbrahimDoğru, Mehmet İlker2022-02-252022-02-2520220275-7540https:/dx.doi.org/10.1080/02757540.2022.2032000https://hdl.handle.net/20.500.12451/9225Although permethrin has low toxicity in mammals, it affects many aquatic organisms directly or indirectly due to its high insecticide potential. In this study, changes in the levels of some hormones, cytokines and histopathological effects in the gill and liver were studied in common carp (Cyprinus carpio) exposed to permethrin at different doses (0, 10 and 20 ppm) and durations (4 days and 21 days). Permethrin exposure showed significant (P < 0.05) elevation in the serum levels of adrenocorticotropic hormone (ACTH), cortisol (CORT), tumor necrosis factor-? (TNF-?), interleukin 1? (IL- 1?) and interleukin 6 (IL-6) while decrease in growth hormone (GH) and insulin-like growth factor-1 (IGF-1) in duration- and concentration dependent-manner compared to the control group. Histopathological findings such as reduction in secondary interlamellar space in the gill tissue, shortening of secondary lamellae, merging, fusion, oedema and telangiectasia were obtained. In the liver tissue, histopathological symptoms such as vacuolization of hepatocytes, passive hyperaemia, mononuclear cell infiltration and hepatocellular degeneration were observed. As a result, it was determined that permethrin had a toxic effect on common carp depending on the dose and duration exposure.eninfo:eu-repo/semantics/embargoedAccessACTH-cortisolCyprinus CarpioGrowth HormoneHistopathologyInterleukinsPermethrinArticle----10.1080/02757540.2022.2032000Q2WOS:000755657300001Q3