Burmaoğlu, SerdarYılmaz, Ali OsmanTaslimi, ParhamAlgül, ÖztekinKılıç, DeryanurGülçin, İlhami13.07.20192019-07-2913.07.20192019-07-2920180365-62331521-4184https://doi.org/10.1002/ardp.201700314https://hdl.handle.net/20.500.12451/5629A series of novel phloroglucinol derivatives were designed, synthesized, characterized spectroscopically and tested for their inhibitory activity against selected metabolic enzymes, including -glycosidase, acetylcholinesterase (AChE), butyrylcholinesterase (BChE), and human carbonic anhydrase I and II (hCA I and II). These compounds displayed nanomolar inhibition levels and showed K-i values of 1.14-3.92nM against AChE, 0.24-1.64nM against BChE, 6.73-51.10nM against -glycosidase, 1.80-5.10nM against hCA I, and 1.14-5.45nM against hCA II.eninfo:eu-repo/semantics/embargoedAccess-GlycosidaseAcetylcholinesteraseButyrylcholinesteraseCarbonic AnhydrasePhloroglucinol DerivativesSynthesis and biological evaluation of phloroglucinol derivatives possessing -glycosidase, acetylcholinesterase, butyrylcholinesterase, carbonic anhydrase inhibitory activityArticle351210.1002/ardp.20170031429323749Q1WOS:000423801700007N/A