Aydın, ÖmerÖzkurt, GüzinÇamkerken, İlkerEren, EmreYanar, Kerim EmreAktaş, Mustafa Sinan2023-09-292023-09-2920230921-4488https:/dx.doi.org10.1016/j.smallrumres.2023.107023https://hdl.handle.net/20.500.12451/11010In this study, the aim was to investigate the thiol/disulfide homeostasis (TDH) parameters and ischemia-modified albumin (IMA) (ABSU) levels to determine oxidative stress in sheep with toxoplasmosis. Twenty-four Morkaraman sheep used in this study were allocated into two groups, one control group and one experimental group. Each group included 12 sheep. Blood samples were taken from all sheep only once and blood serum levels of albumin (ALB) (g/L), IMA (ABSU), native thiol (NT) (?mol/L), total thiol (TT) (?mol/L), disulfide (Ds) (?mol/L), Ds/NT, Ds/TT, NT/TT were investigated. Our results showed that the IMA (ABSU) levels of toxoplasma group were significantly higher than control group (p < 0.05). However, NT (?mol/L) and TT (?mol/L) level of toxoplasma group were significantly lower than the control group (p < 0.05). While the oxidant and antioxidant parameters were positively correlated within themselves, a negative correlation was determined between the antioxidant and oxidant parameters. In the Receiver Operating Characteristic (ROC) analysis, the area under the ROC curve (AUC), sensitivity, cut off and specificity values were determined for IMA (ABSU) values. These values were determined as 0.812, 1.24, 91.7% and 75.0%, respectively. For TT (?mol/L), these values were obtained as 0.750, 330.55, 75.0% and 66.7%. It was concluded that oxidative stress is intensely formed in sheep with toxoplasmosis, thiol-disulphide homestasis markers, and IMA (ABSU) are valuable markers in determining oxidative stress in toxoplasmosis.eninfo:eu-repo/semantics/embargoedAccessIschemia-Modified AlbuminOxidative StressSheepThiol/disulfide HomeostasisToxoplasmosisArticle225Q2WOS:001039003900001Q2