Değirmençay, ŞükrüCamkerten, GüzinCamkerten, İlkerAktaş, M. Sinan2021-04-282021-04-282021https:/dx.doi.org/10.24099/vet.arhiv.0867https://hdl.handle.net/20.500.12451/7914*Camkerten, Güzin ( Aksaray, Yazar ) *Camkerten, İlker ( Aksaray, Yazar )This study aimed to investigate the diagnostic value of thiol/disulfide homeostasis (TDH) and ischemia-modified albumin (IMA) levels in evaluating oxidative stress in dogs with canine distemper. The study materials consisted of 24 cross-breed dogs: 18 dogs with canine distemper (CD group) and 6 healthy dogs as the control. Blood samples for analysis of antioxidant-oxidant parameters were taken from both groups. In addition to TDH parameters (native thiol [NT], total thiol [TT], and disulfide [Ds] levels and Ds/NT, Ds/TT, and NT/TT ratios), IMA and albumin (ALB) levels were also determined in the blood serum of the groups. The IMA levels of the CD group were significantly higher than the control group (P<0.05). Antioxidant parameters (NT, TT) and oxidant parameters (Ds, Ds/NT, and Ds/TT) both exhibited a significant positive correlation among themselves (P<0.01). The areas under the ROC curve of IMA, Ds/NT, and Ds/TT were 0.78, 0.62, and 0.62 respectively. The high levels of IMA, Ds, Ds/NT, and Ds/TT and low levels of NT, TT, NT/TT and ALB in dogs with canine distemper can be used to assess the oxidative stress caused by the disease. Overall, the diagnostic performances of IMA. Ds/NT, and Ds/TT for detection of increased oxidative stress were similar, but IMA was superior.eninfo:eu-repo/semantics/openAccessCanine DistemperOxidative StressThiol/disulfide HomeostasisIschemia-modified AlbuminArticle911394910.24099/vet.arhiv.0867Q4WOS:000621554500005Q4