Öz, MehmetGökbel, Hakkı2023-10-022023-10-0220231995-6673https:/dx.doi.org10.54319/jjbs/160222https://hdl.handle.net/20.500.12451/11037We examined the effects of spirulina supplementation on oxidative status in plasma, liver and muscle tissue and endurance capacity in moderate and exhaustive swimming exercise in rats. Method: Animals were divided into six groups: control, spirulina (SP), chronic exercise (CE), chronic exercise with spirulina (CES), exhaustive exercise (E), and exhaustive exercise with spirulina (ES). Spirulina was administered orally to rats in the SP, CES and ES groups at a dose of 750 mg/kg per day for 6 weeks. The chronic exercise groups underwent swimming exercise for 1 hour/day for 6 weeks. Animals from groups E and ES were subject to exhaustive exercise stress. Creatine kinase (CK), CK-MB, lactate dehydrogenase activities, and uric acid levels were determined in the plasma, whereas malondialdehyde levels and MPO, XO, SOD, CAT, GPx and antioxidant activities were measured in plasma, liver and muscle tissues. Results: Spirulina supplementation attenuated the increase in plasma CK activity induced by exhaustive exercise. Although chronic exercise increased plasma SOD activity, it promoted decreases in liver tissue XO activities and MDA levels as well as muscle tissue MDA levels. Exhaustive exercise reduced liver CAT activities, whereas plasma CAT activities increased. Spirulina supplementation had no effect on endurance capacity in a single session of exhaustive swimming exercise. Conclusion: We concluded that spirulina platensis, ameliorates increases in the plasma activities of CK, probably by decreasing pre-oxidative MDA levels in skeletal muscle.eninfo:eu-repo/semantics/closedAccessAntioxidant StatusEndurance CapacityExerciseMuscle DamageOxidative StressSpirulinaArticle16237137710.54319/jjbs/160222Q2