Noroozi Pesyan, NaderRashidnejad, HamidSafari, ElnazTunç, TuncayAlilou, MostafaSafavi-Sohi, ReihanehŞahin, ErtanEsmaeili, Mohammad Ali2021-02-052021-02-0520200009-4536https:/dx.doi.org/10.1002/jccs.202000057https://hdl.handle.net/20.500.12451/7734Tunç, Tuncay ( Aksaray, Yazar )The reaction of symmetrical (thio)barbituric acids with aldehydes in the presence of 4-methyl morpholine yielded a new form of 4-methyl morpholinium bis-(thio)barbiturate containing charge-separated intermolecular and eight-membered intramolecular H-bonds. X-ray Crystallography, FT-IR, and 1H and 13C-NMR spectroscopy techniques were used for structure characterizations. Some of these compounds showed potent anticancer activities. Cytotoxicity of the synthetic compounds against HeLa and MCF-7 cell lines were performed by MTT assay. In addition, a comparative molecular field analysis was carried out, and the effects of substituents on the biological activities of these compounds were explained.eninfo:eu-repo/semantics/openAccess4-methyl MorpholineAnticancer EffectBarbituric AcidCoMFA StudyEight-membered Intramolecular H-bondNegative Charge-assisted H-bondsResonance-assisted H-bondsArticle6791679169510.1002/jccs.202000057Q2