Köksal, MehmetDoğan, SerapEroz, RecepÖztürk, FigenÖztürk, AhmetCücer, Nurhan2023-10-192023-10-1920230351-60832217-2521https:/dx.doi.org10.5937/afmnai40-35516https://hdl.handle.net/20.500.12451/11187The aim of the paper was to evaluate the AgNOR parameters for the discrimination of benign from malignant breast tumors via a new approach -the total AgNOR area/nuclear area (TAA/NA). Material and methods. Three groups, consisting of control (n = 14), benign (n = 18) and malignant (n = 28) participants were included in the study. The AgNOR staining technique was performed and both mean AgNOR number and TAA/NA ratio were evaluated.Results. While the differences between the control and patient groups were statistically significant for AgNOR number (p < 0.001), it was not significant between the malignant group and the benign group for mean AgNOR number (p > 0.05). For the ratio of TAA/NA, the differences between the control and benign group (p < 0.001), control and malignant group (p < 0.001), and malignant and benign patient groups were significant. (p < 0.05).Conclusion. We consider that the evaluation of the TAA/NA rate, when compared with the AgNOR number, can be more sensitive and useful tool for distinguishing benign from the malignant breast lesions.eninfo:eu-repo/semantics/openAccessBreastbreastBreastBreast CancerNucleolar OrganizingNucleolar Organizing RegionsAgNORArticle4019010110.5937/afmnai40-35516N/A