Rolnick, NicholasClarkson, MatthewKorakakis, VasileiosDe Queiros, VictorPatterson, Stephen D.Buckner, SamuelWerner, TimNascimento, Dahan Da CunhaStray-Gundersen, StenKamış, OkanThoelen, Mathias2025-02-282025-02-2820241664-042Xhttps://dx.doi.org/10.3389/fphys.2024.1482816https://hdl.handle.net/20.500.12451/12981We read with great interest the recent study titled “Cerebral cortex activation and functional connectivity during low-load resistance training with blood flow restriction: An fNIRS study” published in PLOS ONE earlier this year (Jia et al., 2024). The study adds to our limited understanding of the cerebral demands of blood flow restriction (BFR) exercise and the potential role of applied pressure. The authors examined cerebral oxygenation levels following squat exercise performed at 30% of one repetition maximum, with bilateral BFR applied at 150, 250, and 350 mmHg using the B-Strong cuffs (B-Strong, USA). The authors noted enhanced cerebral oxygenation levels in many cortical regions which dropped sharply when 350 mmHg was applied.eninfo:eu-repo/semantics/openAccessArterial Occlusion PressureBFR TrainingCommentaryLimb Occlusion PressureMulti-chambered DesignOther15