Özgen, MerihCoşan, Didem TurgutDoğaner, FulyaSoyocak, AhuArmağan, OnurKuzgun, SelenAydoğan, Ayşe MerveGüneş, Hasan VeysiDeğirmenci, İrfanMutlu, Fezan13.07.20192019-07-1613.07.20192019-07-1620191807-59321980-5322https://doi.org/10.6061/clinics/2019/e739https://hdl.handle.net/20.500.12451/4633OBJECTIVE: In this study, the relationship between osteoporotic vertebral fractures and 9041 Guanine/Adenine and 3673 Guanine/Adenine polymorphisms related to the vitamin K epoxide reductase complex subunit-1 (VKORC1) gene in postmenopausal women with osteoporosis was investigated. METHOD: DNA was isolated from blood samples collected from 150 women with postmenopausal osteoporosis. Genotyping of the two polymorphic regions (9041 Guanine/Adenine and 3673 Guanine/Adenine) in VKORC1 was performed using polymerase chain reaction-restriction fragment length polymorphism analysis. The presence of radiographic fractures among the 150 patients was ascertained by using the Genant method. RESULT: At least one fracture was detected in 98 patients, and no fracture was observed in 52 patients on radiological images. We found no association between the 9041 Guanine/Adenine (p=0.283) and 3673 Guanine/Adenine (p=0.232) polymorphisms of the VKORC1 gene and the development of secondary postosteoporotic fractures in our study. CONCLUSION: There was no relationship between osteoporotic vertebral fracture and VKORC1 gene polymorphism in a postmenopausal Turkish population.eninfo:eu-repo/semantics/openAccessOsteoporosisPolymorphismVitamin K Epoxide Reductase Complex Subunit-1 GeneVertebral FractureArticle7410.6061/clinics/2019/e73930892416Q1WOS:000461832600001N/A