Pesyan, Nader NorooziRashidnejad, HamidEsmaeili, Mohammad AliSafari, ElnazTunç, TuncayAlilou, MostafaSafavi-Sohi, ReihanehŞahin, Ertan2021-06-292021-06-292020https:/dx.doi.org/10.1002/jccs.202000057https://hdl.handle.net/20.500.12451/8214*Tunç, Tuncay ( Aksaray, Yazar )The reaction of symmetrical (thio)barbituric acids with aldehydes in the presence of 4-methyl morpholine yielded a new form of 4-methyl morpholinium bis-(thio)barbiturate containing charge-separated intermolecular and eight-membered intramolecularH-bonds. X-ray Crystallography, FT-IR, and(1)H and(13)C-NMR spectroscopy techniques were used for structure characterizations. Some of these compounds showed potent anticancer activities. Cytotoxicity of the synthetic compounds against HeLa and MCF-7 cell lines were performed by MTT assay. In addition, a comparative molecular field analysis was carried out, and the effects of substituents on the biological activities of these compounds were explained.eninfo:eu-repo/semantics/closedAccess4-methyl MorpholineAnticancer EffectBarbituric AcidCoMFA StudyEight-membered IntramolecularH-bondNegative Charge-assistedH-bondsResonance-assistedH-bondsArticle6791679169510.1002/jccs.202000057WOS:000565364100001Q3