Acat, MuratYıldız Gülhan, PınarEröz, RecepErtınmaz Özkan, AyşegülKoca, OğuzhanÇınar, Caner2023-02-242023-02-2420230301-4851https:/dx.doi.org/10.1007/s11033-023-08244-4https://hdl.handle.net/20.500.12451/10285Aim: The current study aimed to evaluate the effects of caspase-8 (CASP8) and mitogen-activated protein kinase 1 (MAPK1) gene expression levels and their products on preventing severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Methods: A total of 40 patients (men, 15 [37.5%]; women, 25 [62.5%]) with COVID-19 infection were included in the current study. The patients were divided into four main groups based on disease severity: mild (n = 7), moderate (n = 10), severe (n = 14), and critical (n = 9). Individuals aged < 18 years and pregnant women were excluded. Patients were classified according to the World Health Organization (WHO) classification system (WHO/2019-nCoV/clinical/2021.1). Results: Considering all groups, statistically significant differences were detected among all groups for both CASP82???Ct (p = 0.006) and MAPK1 2???Ct values (p = 0.015). Moreover, statistically significant differences were detected between mild and moderate (p = 0.013), moderate and critical (p = 0.018), and severe and critical (p = 0.023) groups for lymphocytes. Conclusion: The CASP8/MAPK1 expression levels and/or its products are essential in preventing injury caused by COVID-19 infection. They play crucial roles in maintaining cellular homeostasis and viability. Furthermore, CASP8/MAPK1 levels can provide information about disease severity.eninfo:eu-repo/semantics/openAccessCASP8 GeneCellular HomeostasisMAPK1SARS-CoV-2Article10.1007/s11033-023-08244-436708447Q2WOS:000921163100001Q3