Synthesis, characterization, and pharmacological evaluation of the proton transfer salts of 2-aminobenzothiazole derivatives with 5-sulfosalicylic acid and their Cu(II) complexes

İlkimen, HalilTeksen, YaseminYenikaya, CengizTurhan, IremTunç, TuncaySarı, Musa13.07.20192019-07-1613.07.20192019-07-1620180095-89721029-0389https://doi.org/10.1080/00958972.2018.1504035https://hdl.handle.net/20.500.12451/4752Two proton transfer compounds, formed between 2-aminobenzothiazole derivatives (2-aminobenzothiazole (abt) and 2-amino-6-ethoxybenzothiazole (EtOabt)) and 5-sulfosalicylic acid dihydrate (H3ssa) as parent compounds, (Habt)(+) (H2ssa)(-) (1) and (HEtOabt)(+) (H2ssa)(-) (2) and their Cu(II) complexes (3 and 4, respectively) have been prepared and characterized using spectroscopic techniques. The single crystal X-ray diffraction method has been also applied to 3 and 4. Although 3 has a distorted octahedral form, 4 exhibits a distorted square pyramidal geometry. All compounds, including saline and diclofenac sodium as standards, have been evaluated pharmacologically for their anti-inflammatory and analgesic activities in rats and mice. Parent compounds (abt, EtOabt, and H3ssa) 3 and 4 showsignificant anti-inflammatory and analgesic activities as compared with control compounds. [GRAPHICS] .eninfo:eu-repo/semantics/closedAccess2-Aminobenzothiazole Derivatives5-Sulfosalicylic AcidProton Transfer SaltAnti-inflammatory ActivityAnalgesic ActivitySynthesis, characterization, and pharmacological evaluation of the proton transfer salts of 2-aminobenzothiazole derivatives with 5-sulfosalicylic acid and their Cu(II) complexesArticle7116-182831284210.1080/00958972.2018.1504035Q3WOS:000457548200025N/A