Kızıl, Hamit EmreÇağlayan, CüneytDarandelioğlu, EkremAyna, AdnanGür, CihanKandemir, Fatih MehmetKüçükler, Sefa2023-02-272023-02-272023https:/dx.doi.org/10.1007/s11033-023-08286-8https://hdl.handle.net/20.500.12451/10298Organ toxicity limits the therapeutic efficacy of methotrexate (MTX), an anti-metabolite therapeutic that is frequently used as an anti-cancer and immunosuppressive medicine. Hepatocellular toxicity is among the most severe side effects of long-term MTX use. The present study unveils new confirmations as regards the remedial effects of morin on MTX-induced hepatocellular injury through regulation of oxidative stress, apoptosis and MAPK signaling.eninfo:eu-repo/semantics/embargoedAccessApoptosisHepatotoxicityMethotrexateMorinOxidative StressArticle10.1007/s11033-023-08286-836781607Q2WOS:000930317000003Q3