The use of magnetic nanoparticles in postoperative antibiotherapy

Abstract

Despite the sterilisation of instruments used in operations, the development of infections after surgical interventions is the leading complication encountered in surgery today. As a result of postoperative complications and the many side-effects of the drugs used for the treatment of these, alternative treatment methods have been developed and trialled. With the development of various nanoparticles, as products of nanotechnology, studies on drug administration methods and their effects have shown a great development in this field. These are used to a great extent in pharmacology and the medical industry, in areas such as disease diagnosis, tissue engineering, and controlled drug release systems. Controlled drug release is the release of an active agent at a predetermined rate within a specific time. One of the most common methods used in controlled drug release is magnetic controlled systems, which provide control beyond the localisation of the drug. Together with the developments in drug technology, these systems, known as smart drug systems, which provide localisation of the drug in the infection region, have attracted great interest recently. As a result of the research into the methods of drug delivery and associated effects, magnetic nanoparticles are considered an alternative method in various treatments.