Browsing by Author "Kerimoğlu, Barış"
Now showing items 1-5 of 5
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Antitumor and apoptotic effects of new-generation platinum compounds on human leukemia cell lines HL-60 and K562
Karacaer, Neslihan Tekin; Kerimoğlu, Barış; Baran, Talat; Tarhan, Mehtap; Menteş, Ayfer; Öztürk, Kamile (Springer, 2022)The goal of this investigation is to report the fabrication, characterization, cytotoxicity, and apoptotic assessment of new platinum based compounds on K562 and HL-60 human leukemia cells. Two new platinum (II) compounds, ... -
The combined effects of proteasome inhibitor bortezomib with topoisomerase I and II inhibitors on topoisomerase enzymes
Öksüzoğlu, Emine; Tırınoğlu, Çiydem; Kerimoğlu, Barış (Tübitak, 2016)Background/aim: DNA topoisomerases are ubiquitous enzymes that regulate conformational changes in DNA topology during essential cellular processes, and, for this reason, have been characterized as the cellular targets of ... -
Cytotoxic and apoptotic activities of novel Pd(II) complexes against human leukemia cell lines in vitro
Tekin, Neslihan; Öztürk, Kamile; Baran, Talat; Kerimoğlu, Barış; Tarhan, Mehtap; Menteş, Ayfer (Taylor & Francis, 2017)In the investigation for alternative chemotherapeutic strategies against leukemia, Pd(II) complexes were synthesized and investigated for cytotoxic and apoptotic properties on two human leukemia cell lines (HL-60 and K562). ... -
Investigation of the possible effect of s-allyl-l-cysteine on apoptosis and autophagy in human leukemia cell line
Tekin Karacaer, Neslihan; Kerimoğlu, Barış; Tarhan, Mehtap; Öztürk, Kamile (Afyonkarahisar Sağlık Bilimleri Üniversitesi, 2021)S-Allyl-L-cysteine (SAC) is a biological active organosulfur component of garlic and has various pharmacological effects. SAC has displayed anti-cancer activity but the mechanism is unresolved. This study has focused on ... -
Proteozom inhibitörü bortezomib ve topoizomeraz inhibitörleri camptothesin ve etoposidin myeloid lösemi hücre hatlarında nf-κb sinyal yolağı ve apoptozis üzerine etkilerinin araştırılması
Kerimoğlu, Barış (Aksaray Üniversitesi Fen Bilimleri Enstitüsü, 2015)Nükleer faktör kappa B (NF-κB) tümör oluşumu ile doğrudan ilişkili olan hücre proliferasyonu, apoptozis, anjiogenez ve metastazın yanında, bağışıklık sistemi ve inflamasyon gibi birçok önemli olayda rol alan 500'den fazla ...
