Aksaray Üniversitesi Kurumsal Akademik Arşivi
DSpace@Aksaray, Aksaray Üniversitesi tarafından doğrudan ve dolaylı olarak yayınlanan; kitap, makale, tez, bildiri, rapor, araştırma verisi gibi tüm akademik kaynakları uluslararası standartlarda dijital ortamda depolar, Üniversitenin akademik performansını izlemeye aracılık eder, kaynakları uzun süreli saklar ve telif haklarına uygun olarak Açık Erişime sunar.
Güncel Gönderiler
Predictive insights into arsenic remediation: Advancing electro and chemical coagulation through machine learning models
(Elsevier Ltd, 2025) Dönmez Öztel, Merve; Alver, Alper; Akbal, Feryal; Altaş, Levent; Kuleyin, Ayşe
Arsenic contamination in water sources remains a critical environmental and public health challenge, mainly due to the toxicity of its trivalent (As(III)) and pentavalent (As(V)) forms. This study compares advanced predictive modeling to enhance arsenic remediation, comparing electrocoagulation (EC) and chemical coagulation (CC) processes for their efficiency and cost-effectiveness. Higher As(III) removal rates were achieved using iron and aluminum electrodes in EC (up to 99 % in 5 min using Fe electrodes) compared to CC (up to 90 % using Fe(II) coagulant). The study's results highlight the operational advantages of EC, including a 40 % cost reduction due to lower chemical usage and sludge production. Machine learning models, including Support Vector Machines (SVM), Regression Trees, Random Forest, and Gradient Boosting, were developed to predict removal efficiencies under diverse operational conditions. SVM exhibited the highest predictive accuracy for As(III) removal in EC with Fe electrodes (MSE = 0.340, R2 = 0.954). At the same time, Regression Trees outperformed other models for As(V) removal in CC with Fe(III) coagulants (MSE = 0.371, R2 = 0.997). These techniques are highly effective in optimizing arsenic removal processes, allowing for precise regulation of treatment parameters and reducing dependence on trial-and-error methods. The findings highlight electrocoagulation with iron electrodes as a sustainable and cost-effective approach to arsenic remediation, particularly for As(III), while underscoring the transformative role of predictive modeling in water treatment. This study successfully integrates experimental insights with machine learning, driving improvements in the efficiency and adaptability of arsenic removal technologies.
Determination of the Experiences of Patients Transferred from the Intensive Care Unit to the Ward
(Multidisciplinary Digital Publishing Institute (MDPI), 2025) Tekinsoy Kartın, Pinar; Bozot Kayasan, Dilek; Özdemir, Ülkü
Patients in intensive care units (ICUs) face factors that cause anxiety, fear, pain, depression, and adverse health behaviors. This qualitative study aims to determine patients’ experiences when transferred from the ICU to the ward. Methods: Thirteen individuals who were transferred from the ICU to the ward were included in this study. Interviews were conducted using a face-to-face method in the patient’s room. The interviews were recorded with a voice recorder with the consent of the patients. Codes, categories, and themes were created, and content analysis and descriptive analysis were carried out after the audio recordings were converted into text. Results: Patients reported receiving adequate physical and personal care in the ICU and were satisfied with its continuity. They felt safe due to the close attention of healthcare professionals and continuous treatment. Although they received psychological and social support from nurses, they were negatively affected by constant lights, patient noises, and nursing conversations. Patients experienced anxiety about not knowing the health status and time of day, about their relatives, their homes, and other critically ill patients in intensive care. Some patients reported fear of not being able to leave the intensive care unit, relapse, disability, or death. Patients reported pain due to the cold environment, lighting, probes, drains, and positioning. Patients suggested that healthcare personnel communicate better with them, have a clock they can see, reduce noise, and have caregivers of the same gender. They emphasized the need for moral support. Conclusions: Constant light in the intensive care unit, sounds from other patients, nurses talking among themselves, not being able to see their relatives, not knowing what time of day it is, and wondering caused anxiety in the patients. It was determined that patients experienced pain due to catheter, drain, aspiration procedures, cold environment, and position in bed. Notably, patients reported that they needed moral support and wanted to receive care from caregivers of the same gender.
Effects of Morin on the Wnt, Notch1/Hes1, KI-67/3-Nitrotyrosine and Damage Signaling Pathways in Rats Subjected to Experimental Testicular Ischemia/Reperfusion
(Springer International Publishing, 2025) Öztürk, Ayşe Betül; Şimşek, Hasan; Akaras, Nurhan; Kandemir, Fatih Mehmet
Testicular torsion, which occurs when the testicle rotates around the axis of the spermatic cord, is a serious cause of hospital admission, mostly in newborns and children, but also in adults. Oxidative stress is an important mediator of the development of complications. Morin has anti-inflammatory, anti-autophagic, and anti-apoptotic activities and especially strong antioxidant activity. This study aimed to determine the effects of Morin on testicular torsion injury. Methods: 35 Wistar rats were divided into 5 groups (n = 7): Control, Morin, I/R, I/R + MRN50, and I/R + MRN100. Parameters are effective in oxidative stress, inflammation, endoplasmic reticulum stress, apoptosis, and autophagy damage and Wnt pathway parameters, KI-67, and 3-NT levels were analyzed by biochemical, molecular, and histological methods. Results: I/R injury significantly increased oxidative stress (MDA, p < 0.001) and reduced antioxidant activity (GSH, SOD, CAT, GPx; p < 0.001). MRN administration reversed these effects, with higher doses showing greater improvement (p < 0.01 for CAT, p < 0.001 for others). Inflammation markers (NF-kB, IL-1β, TNF-α, COX-2, iNOS) were elevated in the I/R group, but MRN reduced their expression (p < 0.001). MRN also mitigated ER stress and reactivated the Wnt signaling pathway, particularly at 100 mg/kg (p < 0.001). Additionally, MRN reduced apoptosis (Caspase-3, Bax, p < 0.001) and autophagy (Beclin-1, LC3A, LC3B, p < 0.001), and improved testicular histology and sperm parameters. MRN treatment restored sperm density, motility, and viability (p < 0.05), with higher doses proving more effective. Conclusion: MRN has effects properties in testicular I/R injury by inhibiting many damage pathways and activating protective mechanisms.
Determination of the effect of Tarantula cubensis alcoholic extract on cadmium embryotoxicity
(Urmia University - Faculty of Veterinary Medicine, 2025) Canbar, Rahmi; Akçakavak, Gökhan; Uslu, Muhittin; Arslan, Mustafa Sedat; Kızılay, Harun
Tarantula cubensis alcoholic extract (TCAE) is a homeopathic product used in the veterinary field. This study aimed to determine the effects of TCAE on cadmium (Cd) toxicity in the embryo. The study used 220 fertile, incubated chicken eggs divided into 11 equal groups on the 7th day of incubation. The groups comprised untreated and physiological saline control groups, a group with TCAE alone, four groups with varying doses of Cd alone and four groups with the same doses of Cd plus TCAE. At the end of the incubation period, the eggs were opened, kidney and liver tissue samples were taken for histopathology and the number of dead and living embryos were recorded. In the prsent study, the median lethal dose of Cd was determined to be 0.029 mg per egg and the median lethal dose of Cd plus TCAE was determined to be 0.020 mg per egg. The histopathological examinations determined that kidney and liver damage were increased when TCAE and Cd were administered together, that was higher than when Cd was given alone. Thus, TCAE, which had no toxic effect on the embryo when used alone, might increase the embryotoxic activity of Cd. However, more detailed studies are needed.
Ameliorative effect of morin on diclofenac-induced testicular toxicity in rats: An investigation into different signal pathways
(Mashhad University of Medical Sciences, 2025) Şimşek, Hasan; Akaras, Nurhan; Gür, Cihan; Küçükler, Sefa; İleritürk, Mustafa; Kandemir, Fatih Mehmet
Diclofenac (Diclo) is a therapeutic agent used in the treatment of pain and inflammatory diseases, but it is also toxic to the human body. Morin is a flavonoid found naturally in plants and has many biological and pharmacological activities, including anti-inflammatory, anti-oxidant, and anticancer activities. This study aimed to investigate the efficacy of Morin in Diclo-induced testicular toxicity. Materials and Methods: Morin (50 mg/kg and 100 mg/kg) was administered orally for five days, while Diclo was administered intraperitoneally at 50 mg/kg on days 4 and 5. Biochemical, molecular, and histological methods were used to investigate oxidative stress, inflammation, apoptosis, and endoplasmic reticulum (ER) stress damage indicators in testicular tissue. Results: Morin treatment attenuated Diclo-induced oxidative stress damage by increasing anti-oxidant levels (SOD, CAT, GPx, GSH, Nrf-2, HO-1, and NQO1) and decreasing MDA levels, an indicator of lipid peroxidation. Morin reduced levels of the inflammatory mediators NF-κB protein. Increases in apoptotic Bax and Caspase-3 by Diclo were reduced by Morin, while decreased antiapoptotic Bcl-2 level was increased. Morin reduced Diclo-induced ER stress injury by decreasing ATF-6, PERK, IRE1, GRP-78, and CHOP levels. Also, Diclo decreased COX-2 levels. Conclusion: Overall, Morin may be an effective treatment of choice for testicular tissue damage associated with Diclo toxicity and may reduce the level of damage.
