Browsing by Author "Öztürk, Kamile"
Now showing items 1-17 of 17
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Aberrant expressions of leptin and adiponectin receptor isoforms in chronic myeloid leukemia patients
Öztürk, Kamile; Avcu, Ferit; Ural, A. Uğur (Academic Press, 2012)Background: Leptin and adiponectin receptors mediate the role of leptin in stimulating the growth of leukemic cells and the protective function of adiponectin undertaken in several malignancies such as leukemia. In this ... -
Antitumor and apoptotic effects of new-generation platinum compounds on human leukemia cell lines HL-60 and K562
Karacaer, Neslihan Tekin; Kerimoğlu, Barış; Baran, Talat; Tarhan, Mehtap; Menteş, Ayfer; Öztürk, Kamile (Springer, 2022)The goal of this investigation is to report the fabrication, characterization, cytotoxicity, and apoptotic assessment of new platinum based compounds on K562 and HL-60 human leukemia cells. Two new platinum (II) compounds, ... -
Apoptotic effect of bortezomib on pancreatic islet cells in STZ-induced diabetic rats
Ekin, Çiğdem; Tekin Karacaer, Neslihan; Tarhan Karaoğlan, Mehtap; Örün, İbrahim; Öztürk, Kamile (Universitas Indonesia, 2022)This study aimed to investigate the possible apoptotic role of bortezomib (BMZ) on pancreatic islets of streptozotocin (STZ)-induced diabetic rats.Methods: Sprague-Dawley rats were divided into groups that were administered ... -
Critical-size alveolar defect treatment via TGF-ss 3 and BMP-2 releasing hybrid constructs
Alıcı Garipcan, Aybüke; Korkusuz, Petek; Bilgiç, Elif; Aşkın, Kerem; Aydın, Halil M.; Öztürk, Eda; İnci, İlyas; Özkızılcık, Asya; Öztürk, Kamile; Pişkin, Erhan; Vargel, İbrahim (Taylor & Francis Ltd, 2019)In the present study a combination of Transforming Growth Factor Beta 3 (TGF-beta 3) and Bone Morphogenetic Protein-2 (BMP-2) loaded gelatin films sandwiched between poly (L-lactide) (PLLA)/poly (epsilon-caprolactone) (PCL) ... -
Cytotoxic and apoptotic activities of novel Pd(II) complexes against human leukemia cell lines in vitro
Tekin, Neslihan; Öztürk, Kamile; Baran, Talat; Kerimoğlu, Barış; Tarhan, Mehtap; Menteş, Ayfer (Taylor & Francis, 2017)In the investigation for alternative chemotherapeutic strategies against leukemia, Pd(II) complexes were synthesized and investigated for cytotoxic and apoptotic properties on two human leukemia cell lines (HL-60 and K562). ... -
Genotoxicity of potent antiviral 1-[(2-aminophenyl)thio]- 1-phenyl-2-nitrobutane derivatives designed as drug agents
Doğan, Tuğba Somay; Durusoy, Mübeccel; Gökçe, Mehtap; Öztürk, Kamile (Türk Biyokimya Derneği, 2014)Objective: Genotoxic potentials of six selected nitrobutane (I) derivatives designed as drug agents were tested here for the first time using umu-microplate test system. An important principle in drug development is to ... -
Gold nanoparticles loaded TNF-α and CALNN peptide as a drug delivery system and promising therapeutic agent for breast cancer cells
Jabir, Majid S.; Abood, Noor A.; Jawad, Marwa H.; Öztürk, Kamile; Kadhim, Haider; Albukhaty, Salim; Al-Shammari, Ahmed; AlMalki, Faizah A.; Albaqami, Jawaher; Sulaiman, Ghassan M. (Taylor and Francis Ltd., 2022)We investigated the anti-cancer properties of gold nanoparticles loaded TNF- and CALNN peptides, which we proposed as a potential drug delivery system using in vitro and in vivo models. The binding of GNPs-TNF- and ... -
HSP27 inhibitörü brivudin'in bortezomible birlikte multiple myeloma tedavisinde kullanılabilirliğinin araştırılması
Tetik, Ayşegül (Aksaray Üniversitesi Fen Bilimleri Enstitüsü, 2022)Multiple myeloma (MM) fonksiyonel olmayan monoklonal immunoglobilin üretiminden sorumlu malign plasma hücrelerinin kemik iliğinde birikmesiyle karakterize edilen hematolojik bir kanserdir. Son yıllarda myeloma hücrelerinde ... -
Investigation of the possible effect of s-allyl-l-cysteine on apoptosis and autophagy in human leukemia cell line
Tekin Karacaer, Neslihan; Kerimoğlu, Barış; Tarhan, Mehtap; Öztürk, Kamile (Afyonkarahisar Sağlık Bilimleri Üniversitesi, 2021)S-Allyl-L-cysteine (SAC) is a biological active organosulfur component of garlic and has various pharmacological effects. SAC has displayed anti-cancer activity but the mechanism is unresolved. This study has focused on ... -
Multiple Myeloma'da bortezomibe karşı gelişen direnç mekanizmasında toll like reseptörlerin rolünün araştırılması
Tarhan, Mehtap (Aksaray Üniversitesi Fen Bilimleri Enstitüsü, 2017)Multiple myeloma (MM) kemik iliğindeki plazma hücrelerinin anormal proliferasyonu ve invazyonu ile karakterize edilen, tedavi edilemeyen hematolojik bir kanserdir. Günümüzde MM tedavisi için kullanılan en etkin tedavi ... -
Proteozom inhibitörü bortezomib ve topoizomeraz inhibitörleri camptothesin ve etoposidin myeloid lösemi hücre hatlarında nf-κb sinyal yolağı ve apoptozis üzerine etkilerinin araştırılması
Kerimoğlu, Barış (Aksaray Üniversitesi Fen Bilimleri Enstitüsü, 2015)Nükleer faktör kappa B (NF-κB) tümör oluşumu ile doğrudan ilişkili olan hücre proliferasyonu, apoptozis, anjiogenez ve metastazın yanında, bağışıklık sistemi ve inflamasyon gibi birçok önemli olayda rol alan 500'den fazla ... -
Proteozom inhibitörü bortezomibin tip 1 diyabetin tedavisinde kullanılabilirliğinin in vivo koşullarda araştırılması
Ekin, Çiğdem (Aksaray Üniversitesi Fen Bilimleri Enstitüsü, 2016)Tip 1 Diyabet, pankreasın langerhans adacıklarına inflamatuar hücrelerin infiltrasyonu ve sonrasında insülin salgılayan β hücrelerinin kaybı ile karakterize edilen otoimmün bir hastalıktır. İn vitro ve in vivo olarak ... -
Resveratrol shows vasoprotective effect reducing oxidative stress without affecting metabolic disturbances in insulin-dependent diabetes of rabbits
Akar, Fatma; Pektaş, Mehmet Bilgehan; Tufan, Can; Söylemez, Selen; Sepici, Aylin; Ulus, Ahmet Tulga; Gökalp, Burcu; Öztürk, Kamile; Sürücü, Hüseyin Selçuk (SPRINGER, 2011)Resveratrol has been shown to have vasoprotective effects by upregulating oxidative defense mechanisms in a variety of pathophysiological conditions. However, the effect of resveratrol on diabetic oxidative stress and ... -
TNF-alpha loaded on gold nanoparticles as promising drug delivery system against proliferation of breast cancer cells
Jawad, Marwa; Öztürk, Kamile (Elsevier, 2021)Even though the significant anti tumor effect of Tumor necrosis factor (TNF-alpha) and the essential role in various cellular and immunological properties, the clinical use of TNF-alpha is delayed due to its toxicity. In ...
