Aksaray Üniversitesi Kurumsal Akademik Arşivi
DSpace@Aksaray, Aksaray Üniversitesi tarafından doğrudan ve dolaylı olarak yayınlanan; kitap, makale, tez, bildiri, rapor, araştırma verisi gibi tüm akademik kaynakları uluslararası standartlarda dijital ortamda depolar, Üniversitenin akademik performansını izlemeye aracılık eder, kaynakları uzun süreli saklar ve telif haklarına uygun olarak Açık Erişime sunar.
Güncel Gönderiler
Biomedical applications of biopolymer-based (nano)materials
(Elsevier, 2021) Nasrollahzadeh, Mahmoud; Bidgoli, Nayyereh Sadat Soheili; Soleimani, Fahimeh; Shafiei, Nasrin; Nezafat, Zahra; Baran, Talat
Nanotechnology has an important role in biomedical application, and thus, different nanoparticles have been designed for utilization in this area. Among them, metal nanoparticles (MNPs) have excellent properties and potentials. Their performance can be improved by immobilizing them on a suitable support. Biopolymers can be used in different medical applications such as drug delivery, wound healing, bioimaging, tissue engineering, and sensing with respect to their biodegradability, biocompatibility, and other different properties. They also can be ideal supports for the fabrication of different types of MNPs. This chapter explains some examples of biopolymer-based (nano)materials and their biomedical applications.
Molecular imprinted sensors for Ion-Sensing
(Elsevier, 2021) Çimen, Duygu; Topçu, Aykut Arif; Özbek, Merve Asena; Bereli, Nilay; Denizli, Adil
Metal ions play a pivotal role in biological process, which act as an actor to protect the stabilities of enzymes and proteins and help to carry out their functionalities with permissible limits, however, some metal ions such as cadmium, arsenic can lead to enzyme inhibition, induce the oxidative stress and unwanted conditions like the impairment of mismatch mechanism. Hence, the monitoring of metal ions including trace metals is great importance not only living beings but maintain the ecosystem also. Currently available methods for determination of metal ions include inductively coupled plasma mass spectrometry (ICP-MS), atomic absorption spectrometry (AAS), and high-performance liquid chromatography (HPLC). While these chromatographic and analytical methods offer high sensitivity and selectivity, these costly instruments require intense technical training because of their time consuming and complicated procedures. In recent years, sensors have several advantages over other analytical methods. Sensors are more preferred compared to analytical methods and have attractive increasing attention because of their high sensitivity, low cost, fast response, portability, simple operation, and on-site operation. In this chapter, we first summarized the importance of metal ions for life-balance for biological processes, after the commonly used methods for detection of metal ions including sensor platforms were discussed with the latest research articles by the combining of molecular imprinting technology.
The symmetric and asymmetric time-varying causality relationships between the covid-19 outbreak and the stock exchange: the case of selected countries
(Vilnius University Press, 2021) Demirtaş, Cuma; Ilıkkan Özgür, Munise; Soyu, Esra
In this study, the effects of COVID-19 (mortality rate, case rate, and bed capacity) on the stock market was examined within the framework of the efficient market hypothesis. Unlike other studies in the literature, we used the variable of bed capacity besides the mortality rate and case rate variables. The relationship between the mentioned variables, using daily data between December 31 of 2019 and November 10 of 2020, has been analyzed with time-varying symmetric and asymmetric causality tests for China, Germany, the USA, and India. Considering that the responses to positive and negative shocks during the pandemic process may be different and that the results may change depending on time, time-varying symmetric and asymmetric causality tests were used. According to the time-varying symmetric causality test, stock markets in all countries were affected in the period when the cases first appeared. A causal relationship between COVID-19 and country stock markets was found. The results showed that the effects of the case rate and bed capacity on the stock market occurred around the same time in Germany and the United States; however, these dates differed in China and India. According to time-varying asymmetric causality test findings, the asymmetric effect of the pandemic on the stock market in countries emerged during the second wave. The findings showed that the period during which positive and negative information about the pandemic intensified coincided with the period during which the second wave occurred; besides, the results show the effect of this information on the stock market differed as positive and negative shocks.
Effect of supplementation of nano zinc in male quail diets on performance, some blood parameters, testis morphology and meat colour properties
(University of Agriculture, 2021) Sevim, Behlül; Olgun, Osman
This research was conducted to determine the effects of different levels (0, 50 or 100 mg/kg) of nano zinc (nano Zn) supplementation as a zinc source in male Japanese quail (Coturnix coturnix Japonica) diets on performance, some serum parameters, testis characteristics and meat colour. In the four-week study, a total of 60 male Japanese quails (190.4 ± 2.4 g body weight) at the age of 49 days were distributed to three treatment groups and each treatment group was divided into four subgroups, each containing five male quails. As a result of this study, in the current study, the addition of nano Zn to the diet had no effect on feed intake, testis morphology, serum cholesterol, total protein, calcium and phosphorus levels (P>0.05). Addition of nano Zn to diet increased body weight gain (BGW) (P<0.05). With the addition of nano Zn, serum glucose level increased while serum triglyceride level decreased (P<0.05). Breast and thigh + drumstick L* values among meat parameters increased with the addition of nano Zn to male quail diets (P<0.05). As a result, adding nano Zn to male quail diets increased serum glucose level and meat L* value, decreased serum triglyceride concentration, and testis morphology was not affected.
Effectiveness of repetitive transcranial magnetic stimulation in patients with failed back surgery syndrome: a double-blind randomized placebo-controlled study
(American Society of Interventional Pain Physicians, 2021) Bursalı, Canan; Ünlü Özkan, Feyza; Yılmaz Kaysın, Meryem; Dörtcan, Nimet; Aktaş, İlknur; Geler Kulcu, Duygu
Background: Failed back surgery syndrome (FBSS) is the term of persistent back /and or leg pain after lumbar surgery. Repetitive transcranial magnetic stimulation (r-TMS) is a technique that allows noninvasive and relatively painless stimulation of cerebral cortex. It can reduce the experience of chronic pain by producing the small electrical currents in the cortex via magnetic field. Objectives: The aim of this study is to determine the effectiveness of r-TMS treatment on patients with FBSS. Study Design: A double-blind, randomized, placebo-controlled trial. Setting: The Physical Medicine and Rehabilitation Clinic of Istanbul Fatih Sultan Mehmet Training and Research Hospital, Istanbul, Turkey. Methods: In this double-blinded, randomized, placebo-controlled trial, 20 patients (aged 34-65 years) clinically diagnosed as FBSS who had a history of surgery for lumbar disc herniation with persistent back and leg pain were reviewed. Only patients with no root compression and or spinal stenosis in postoperative magnetic resonance imaging of lumbar spine were included. Patients were randomly assigned to r-TMS (n:10) and sham (n:10) groups. Patients in the r-TMS group received 5 Hz of r-TMS as a 20-minute (1,000 pulses) daily session, 5 days per week, for a total of 10 sessions. r-TMS was applied with MagVenture device (MagPro X100, Denmark, 2009) and figure 8 coil (MMC 140 parabolic, MagVenture). Control group received sham r-TMS with the same protocol. Each patient was evaluated at baseline, days 5 and 10 of treatment, and 1 and 3 months after treatment. Visual Analog Scale (VAS), DN4 (Douleur Neuropathique en 4 Questions), Oswestry Disability Index (ODI), Beck Depression Inventory (BDI), and the Pittsburgh Sleep Quality Index (PSQI) were used for evaluation. Results: There were no statistically significant differences between the groups for age, gender, number of surgeries, pain duration, working status, and drug usage. Significant improvements were achieved in DN4, ODI, BDI, and PSQI scores in the r-TMS group in comparison to the sham group. Both groups displayed improvements in VAS scores, whereas improvement in the sham group was limited to the first month. Achieved improvements in the r-TMS group in terms of VAS, DN4, ODI, BDI, and PSQI scores were sustained at the third month. Limitations: The limited number of patients and the short follow-up periods are the main limitations of our study. Further placebo-controlled studies with longer follow-up periods and greater number of cases would be beneficial for examining r-TMS application as a new treatment option in patients with FBSS. Conclusions: r-TMS might be an effective alternative treatment in patients with FBSS, further studies with larger groups are needed.
