Aksaray Üniversitesi Kurumsal Akademik Arşivi
DSpace@Aksaray, Aksaray Üniversitesi tarafından doğrudan ve dolaylı olarak yayınlanan; kitap, makale, tez, bildiri, rapor, araştırma verisi gibi tüm akademik kaynakları uluslararası standartlarda dijital ortamda depolar, Üniversitenin akademik performansını izlemeye aracılık eder, kaynakları uzun süreli saklar ve telif haklarına uygun olarak Açık Erişime sunar.
Güncel Gönderiler
First report on the ısolation of salmonella enterica subsp. enterica serovar hofit in wild boars (sus scrofa) in Türkiye
(Mary Ann Liebert Inc., 2025) İlhan, Ziya; Hasdoğan, Harun; Gökmen, Mukadderat
The aim of this study was to isolate potential bacterial pathogens, such as Salmonella spp., from wild boars (Sus scrofa) inhabiting the Southern Marmara Region of Turkiye and to evaluate the in vitro antibiotic susceptibility of the isolates. Samples, including feces and internal organs (lymph nodes, liver, lungs, kidneys, and spleen), were collected from a total of 34 legally hunted wild boars. Salmonella enterica subsp. enterica serovar Hofit was isolated from 6 (17.6%) animals. Ciprofloxacin, streptomycin, ampicillin, tetracycline, chloramphenicol, enrofloxacin, gentamicin, ceftiofur, cefoxitin, nalidixic acid, amoxicillin/clavulanic acid, and trimethoprim/ sulfamethoxazole discs were used to determine the in vitro antimicrobial susceptibility of S. Hofit isolates. All S. Hofit isolates had 100% sensitivity to 11 of the antibiotics tested, and three isolates were resistant only to streptomycin. As a result, this study is the first to report the isolation of S. Hofit from wild boars worldwide. The high isolation rate (17.6%) suggests a potential adaptation of this serovar to swine hosts. The apparent prevalence of S. Hofit in wild boars raises concerns not only for wildlife but also for potential public health implications.
The effect of cherry laurel, rutin flavonoid and α-lipoic acid on streptozotocin and nicotinamide ınduced type 2 diabetic rats given metformin
(Springer International Publishing, 2025) Kaya Kartal, Yeliz; Pekcan, Mert; Ahlat, Ozan; Özkurt, Güzin; Kısmalı, Görkem; Gönenç, Aymelek; Sel, Tevhide
Type 2 diabetes, characterized by insulin resistance, is a growing global health concern. The combined use of pharmaceutical medications and natural products for diabetes has become more common in recent years, although it is still unresolved how they might interact. This study aims to investigate the interactive effects of metformin and natural antioxidants—cherry laurel, rutin flavonoids, and α-lipoic acid—on metabolic and histological outcomes in a type 2 diabetes model. Six rat groups were used, five of the groups rendered diabetic using nicotinamide (110 mg/kg) and streptozotocin (65 mg/kg, i.p.). For 12 weeks, animals received oral doses of metformin (500 mg/kg) and the combinations of metformin and natural products. Serum was analyzed for glucose, lipid profile, ceruloplasmin, plasma for nitric oxide and pancreatic tissue for histopathological changes and, insulin immunoreactivity. Ceruloplasmin levels were significantly higher in diabetic rats (22.89 ± 2.85 U/L) compared to the diabetic + metformin + rutin group (14.32 ± 0.73 U/L). Nitric oxide levels were lower in diabetic rats (61.27 ± 6.26 µmol/L) but elevated in the metformin-only group (110.22 ± 11.44 µmol/L). Histopathological evaluation showed pronounced pancreatic atrophy in the diabetic, diabetic + metformin + cherry laurel, and diabetic + metformin + rutin groups, while the diabetic + metformin group exhibited preserved tissue. Interestingly, insulin secretion was lower in the combination therapy groups (especially the use of rutin flavonoid and α-lipoic acid) compared with the control and diabetic + metformin group, suggesting potential antagonistic effects. Although glucose levels were not markedly different across treatment groups, histological findings revealed more pronounced tissue damage in antioxidant-metformin combinations than with metformin alone. These results highlight the importance of evaluating natural product–drug interactions before co-administration.
Correction to: exposure to an electromagnetic field during adolescence can cause destruction and pain in bone tissue and cells while also triggering new bone formation (bratislava medical journal, (2025), 10.1007/s44411-025-00217-2)
(Springer International Publishing, 2025) İkinci Keleş, Ayşe; Kaya, Haydar; Keleş, Gökhan; Tümkaya, Levent
When this article was published, the name of the 3rd author was wrongly given as “Gökhan İkinci Keleş” though it should be correctly “Gökhan Keleş”. The Original article has been corrected. The Publisher apologises for this mistake.
Prognostic value of the hemoglobin, albumin, lymphocyte, platelet score in metastatic mesothelioma: a retrospective study
(S. Karger AG, 2025) Doğan, Özlem; Düzköprü, Yakup; Eren, Tülay
Malignant mesothelioma is a rare but aggressive cancer with limited treatment options and poor prognosis. Hemoglobin, Albumin, Lymphocyte, Platelet (HALP) score, reflecting inflammation and nutritional status, is a potential prognostic marker in various cancers. Our study aimed to investigate the prognostic value of the HALP score in mesothelioma. Methods: This retrospective study included 68 metastatic mesothelioma patients diagnosed between 2015 and 2023. Clinical and laboratory data were collected, and HALP scores were calculated at the time of metastasis. Patients were divided into HALP-low and HALP-high groups based on the median HALP score. Overall survival (OS) and progression-free survival (PFS) were analyzed using the Kaplan-Meier method, and prognostic factors were assessed using univariate and multivariate analyses. Results: The median HALP score was 24.85. The median OS for the entire cohort was 11.59 months. Patients with low HALP scores had significantly worse OS (7.81 months) compared to those with high HALP scores (16.36 months) (p = 0.01). Similarly, median PFS was significantly shorter in the HALP-low group (7.29 months) compared to the HALP-high group (12.12 months) (p = 0.02). In multivariate analysis, low HALP score (p = 0.02) and de novo metastatic disease (p = 0.01) remained independent prognostic factors for OS. Conclusion: This study demonstrates that the HALP score is an independent prognostic biomarker in metastatic mesothelioma. Low HALP scores are associated with worse OS and PFS. Given its simplicity and cost-effectiveness, the HALP score may be a valuable tool for risk stratification and treatment decision-making in clinical practice.
Advancing the thermodynamic approach with the predictive model for the freeze-drying of meat
(Frontiers Media SA, 2025) Öztuna Taner, Öznur
The establishment of innovative engineering techniques for meat products is required because of the significant energy requirements associated with freeze-drying of food products. This study is innovative application research on the freeze-drying of meat process and analyses energy efficiency by employing predictive statistical methods. Thermodynamic laws play a crucial role in the thermodynamic analysis of frozen food processes by regulating the essential operations involved in food production. The thermodynamic evaluation of the freeze-drying of meat process was carried out over a total of 40 scenarios covering 24 h (20 scenarios) and 30 h (20 scenarios). The energy efficiency in the 24 h process fluctuated between 38.7 and 43.1% over the 20 scenarios, whereas in the 30 h process, it varied from 36.9 to 41.1% throughout the 20 scenarios. The analysis revealed that the energy efficiency of the 24 h scenarios exceeded that of the 30 h scenarios, suggesting that 24 h is the optimum period for meat drying. This comparative assessment indicates that shortening the drying duration can deliver substantial energy savings without compromising process effectiveness. Future research will look at the application of this technology to enhance food quality and shelf life by applying a comparable freeze-drying technique to meat in various food industries.
