Aksaray Üniversitesi Kurumsal Akademik Arşivi
DSpace@Aksaray, Aksaray Üniversitesi tarafından doğrudan ve dolaylı olarak yayınlanan; kitap, makale, tez, bildiri, rapor, araştırma verisi gibi tüm akademik kaynakları uluslararası standartlarda dijital ortamda depolar, Üniversitenin akademik performansını izlemeye aracılık eder, kaynakları uzun süreli saklar ve telif haklarına uygun olarak Açık Erişime sunar.
Güncel Gönderiler
Could nucleolin and nucleophosmin levels be prognostic indicators in non-small cell lung cancer
(University of Nis, Faculty of Medicine, 2022) Akın, Gül; Eşbah, Onur; Eröz, Recep
Lung cancer is the leading cause of mortality from cancer across the world. In this study, the use of serum nucleolin (NCL) and nucleophosmin (NPM1) levels as a marker in the diagnosis, prognosis and treatment response evaluation in lung cancer was investigated. Materials and Method: NCL and NPM1 levels of serum samples taken before chemotherapy and after 3-4 courses of chemotherapy from the control group and the patients diagnosed with lung cancer were studied using ELISA method. Results: Serum NCL and NPM1 levels of the patients were higher than of the controls (p = 0.085 for NCL, p = 0.000 for NPM1). NCL and NPM1 levels by histopathologic type were significantly higher in adenocarcinoma than in squamous cell carcinoma (p < 0.05 for each). In view of the treatment responses to chemotherapeutic agents, there was a statistically insignificant difference between the values before and after chemotherapy (p > 0.05 for each). Conclusion: High serum NCL and NPM1 levels were found to correlate with poor prognosis, poor treatment response and low survival rate. It can be concluded that serum NCL and NPM1 levels in lung cancer can be used as diagnostic and prognostic markers for the disease. © 2022 Sciendo. All rights reserved.
Nucleophosmin
Integrated education and learning 2050
(Springer Nature, 2022) Rezaei, Nima; Saghazadeh, Amene; Abdurrahman, Abdurrahman; Ciasullo, Alessandro; Liaptsev, Alexander; Lighthill, Brian; Ortega-Sánchez, Delfín; Oner, Diler; Herawaty, Dewi; Dilekli, Yalçın
The authors of Integrated EducationEducationandLearningLearningIntegrated Education and Learning were asked how they would see the futureFuture of their field 30 years later. This chapter presents the authors’ views onSemiotics, cognitivecognitiveSemioticssemioticsCognitive semiotics as an integrated field of scienceScience in 2050, along with thinkingThinkingskillsSkill(computationalThinking, computationalthinkingThinking, scientificThinking, scientificthinkingThinking, and criticalThinking, criticalthinkingThinking); early childhoodChildhoodeducationEducation and its importance in developing a new intelligenceIntelligenceand social andLearning, social and emotionalemotionalLearning, emotionallearningLearning; the role of artsArtin educationEducation and preparing learners for systemsSystemsthinkingThinkingand thinkingThinkingsustainabilitySustainability; futureFuture forms of educationEducationand learningLearning (e-learning, inquiry-based learningLearning, self-directed learningLearning, developmental educationEducation, evidence-based educationEducation, educationEducation of information age, entrepreneurial STEMSTEMeducationEducation, educationEducation for super-smart societySociety), and the role of integratedSciencescienceIntegrated sciencein educationEducation(educationEducationfor equalityEquality and for controlling social and ethical issues). Integrated EducationEducationandLearningLearningIntegrated Education and Learning–Word cloud.
Bio-electrospinfabrication: from production to applications
(World Scientific Publishing Co., 2022) Karahaliloğlu, Zeynep; Kara, Göknur; Denkbaş, Emir Baki
Biofabrication is a technology that has the potential to emerge as the leading manufacturing paradigm of the 21st century with the contributions of engineering, biology, and materials science. Electrospinning, one of the biofabrication techniques, has arisen as a simple and cost-effective fiber-forming technology, since its discovery by Formhals in 1934. Recently, electrospun fibers have gained much attention due to their wide range of uses in diverse application fields. Especially, for manufacturing scaffolds to be used in tissue engineering (TE) applications, electrospun fibers are very promising alternatives that mimic the extracellular matrix (ECM) for cellular progression. However, this technique also has drawbacks such as jet instability, low productivity, the requirement of using specialized equipment, and high voltage besides environmental concerns related to use of organic solvents. Hence, new design strategies and additive manufacturing (AM) approaches are still needed that allow production of many different types of scaffolds as required and so, to precisely control the morphology and diameter of the produced three-dimensional (3D) materials. In this respect, this chapter provides the state of the art of electrospinning by categorizing it into melt electrospinning, solution electrospinning, centrifugal electrospinning, cryoelectrospinning, and near-field electrospinning from the aspects of TE.
Toxicology of nano-scale materials used in water treatment
(ISRES Publishing, 2022) Öztürk, Arzu
In the last two decades, the use of nanomaterials has increased in food ingredient and packaging, water treatment, pesticides, cosmetics and many other industries. Old habits have begun to change in this process and silver nanoparticles instead of pesticides, carbon nanotubes absorbing pollutants in water treatment, titanium dioxide in smart drugs and cosmetics have become widespread. These nanoparticles, which permeate our lives in all areas, can hang in the air for kilometers and can cause DNA damage by penetrating people, animals and plant cells. Although the magnitude of the risks and the toxic effects are estimated, there are very few studies on this subject yet. Therefore, it is required to reveal the risks and toxic effects of nanomaterials, which are described as excellent technology. In this study, the toxicity of nano-scale materials, which are widely used in water treatment, and their effects on human and environmental health were investigated. Thus, the mechanism of action of the investigated nanomaterials was revealed.
Acute generalized exanthematous pustulosis in temporal association with COVID-19 vaccine
(Termedia Publishing House Ltd., 2022) Bayrak Özturk, Simay; Ordu, Melike
Acute generalized exanthematous pustulosis is characterized by small, sterile, non-follicular, and sudden-onset pustular reactions on an erythematous surface. It typically involves intertriginous regions and the trunk and is usually accompanied by itching and a feeling of pain in the lesion areas. Often pharmacological treatments and frequent viral eruptions, including enterovirus, coxsackie, Epstein-Barr virus, and hepatitis B, play a role in the etiology of the disease. Case report: Here, we present the case of acute generalized exanthematous pustulosis in a 17-year-old young woman triggered by the 1st dose of COVID19 mRNA BioNTech vaccine. Conclusions: We are reporting a rare case of vaccine-related acute generalized exanthematous pustulosis, associated with a COVID-19 vaccination. © 2022 Termedia Publishing House Ltd.. All rights reserved.
